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Rats were tasked with performing a series of behavioralĮvaluations: The Morris water maze (MWM) test and a novel object In order to measure the level of improvement, Was to evaluate the effects of γ-oryzanol solid dispersion (GOSD)Īnd curcumin solid dispersion (CURSD) on learning and memory of Therefore, curcumin and γ-oryzanol were prepared in a solidĭispersion to enhance their water solubility. However, studies have found that the beneficial effects of curcuminĪnd γ-oryzanol are limited by their low water-solubility, leading (SOD), catalase (CAT), and glutathione peroxidase (GPx) ( 9-12). Increase antioxidant levels such as those of superoxide dismutase Moreover, these two elements have been identified as compounds that Reported to reduce ROS, oxidative stress, and inflammation. Prevention of brain deteriorationīefore aging is important. Previous studies have shown that a diet rich in antioxidants mayĭecrease the risk of developing various neurodegenerative diseases Increase in reactive oxygen species (ROS) related to theĭiminishing antioxidant defenses, and an increase in chronic
These are the two major aspects that lead to oxidative stress, an Radical levels, with a concurrent decrease in antioxidant levels.
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The major risk factor concerning aging is an increase in free Neuroinflammatory disorders, or Alzheimer's disease ( 1-3). In function, and is subject to several debilitating ailments suchĪs neurodegenerative diseases, cognitive impairment disorders, The brain irreversibly and progressively declines Physiological and morphological changes that occurĭuring aging impact the functional process related to an individual
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The results indicated that GOSD 10 mg/kg plus CURSD 50 mg/kg was able to enhance learning and memory performance in the middle‑aged rats. The rats also exhibited decreased levels of lipid peroxidation, increased superoxide dismutase levels, glutathione peroxidase levels, catalase activity, and enhanced c‑Fos expression both in the hippocampus and prefrontal cortex. The GO‑HCur group exhibited significantly increased learning and memory performance in a Morris water maze and in reacting to a spontaneous tendency novel object test. Substances were administrated by oral gavage once daily for 42 consecutive days. The groups were labeled as the control group, the GO group (GOSD 10 mg/kg♻W), the Cur group (CURSD 50 mg/kg♻W), the GO‑LCur group (GOSD 10 mg/kg♻W plus CURSD 25 mg/kg♻W), and the GO‑HCur group (GOSD 10 mg/kg♻W plus CURSD 50 mg/kg♻W). Group one was the adult control consisting of 6‑week old male rats, and the remaining five groups consisted of 42‑week (middle‑aged) male rats. This study aims to evaluate the effects and mechanisms of γ‑oryzanol solid dispersion (GOSD) and curcumin solid dispersion (CURSD) on learning and memory in six groups of male rats (n=5/group). Thus, a solid dispersion technique was used to prepare curcumin and γ‑oryzanol to enhance their solubility and stability. However, curcumin and γ‑oryzanol exhibit low aqueous solubility. Several studies have reported that curcumin and γ‑oryzanol exhibits anti‑oxidant and anti‑inflammatory properties. Memory loss can begin in middle‑aged individuals, so prevention of brain deterioration before aging is important. Oxidation causes molecular alterations, structural damage, and brain dysfunction, which includes cognitive impairment. Oxidative stress is one of the major factors that contributes to brain deterioration in the elderly.
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